Using Sulfonylureas as Diabetic Medications
Sulfonylurea medicines are a kind of anti diabetic drugs which can be useful to help deal with type 2 diabetes. They basically act positively by increasing insulin release within the beta cells inside the pancreas. It is strongly recommended that you avoid skipping any meals if you are using sulfonylureas. The reason is , the drugs will probably cause your beta cells to create more insulin throughout the day. The blood glucose levels in your body can go too low causing great complications if you do skip meals. You have to also adhere to a good meal routine as well as eat even during the times you're not hungry. You can ensure that your insulin has the needed amount of glucose to help process your throughout the day, by doing so.
Type 2 diabetes has been characterized by gradual declines inside the glycaemic control and the progression of oral glucose-lowering monotherapy by creating a combination therapy and a exogenous insulin therapy. The functional decline of insulin-secreting b-cells are largely responsible for common deterioration with glycaemic control. The preservation of b-cell functionality as well as maintaining glycaemic control to reduce insulin resistance has now regarded to be the key target for long term management strategies.
The more early aggressive interventions with combination therapy has emerged as an effective approach to optimize long term outcomes to combine agents with the differing modes of such action and secondary-effect profiles to prove as valuable. Sulfonylureas exert the glucose-lowering effects through differing the mechanisms of action which stimulate insulin secretion, whereas thiazolidinediones are the insulin sensitizers. Both the agents offer superior improvements with glycaemic control when it is given as a monotherapy or given in combination. The common thiazolidinediones was made to protect b-cell functional and structural integrity and functionality to complement the sulfonylureas from inducing and maintaining the improvements in the insulin resistance and the abnormal lipid profiles associated with diabetes.
Some types of medicines that may interact with Sulfonylureas
- certain types of antibiotics like sulfonamides, rifampicin, chloramphenicol and tetracyclines
- medicines that could have hypoglycaemic effect like warfarin and heparin which is used to prevent blood clots
- depressive disorder medicines
- Yeast infections and fungal medicines like miconazole, ketoconaole and fluconazole
Sulfonylureas for treating type 2 diabetes
Thus, there's a very strong rationale that supports the addition of the thiazolidinediones to sulfonylureas for treating type 2 diabetes. The combination can particularly be effective in early stages of this disease when b-cell functions are at its highest. The reason to this is that it allows maximal benefits to be obtained in the insulin secretion by promoting abilities of sulfonylureas and b-cell-protective effects from the thiazolidinediones.
Sulfonylurea medicines became available first in 1955 and has since been deemed as one of the most effective medicines for type 2 diabetes. Since sulfonylureas medication only works by stimulating your pancreas to release such insulin, they only become useful within those dealing with type 2 diabetes. Also it can also be used by patients with beta cells that can naturally still produce insulin. Furthermore, although sulfonylureas does stimulate the releasing of insulin, they don't reduce insulin resistance which is a common factor in type 2 diabetes.
Since sulfonylureas has been available for many years now, they have been characterized as non-harmful. These medicines are also considered to be the core treatment, for type 2 diabetes. In turn, sulfonylureas medicines have become the most recommended medicines for people with type 2 diabetes to invest their money in.