Sulfonylureas have been used for ages as a cornerstone in the management of Type 2 diabetes. The best sulfonylureas include glipizide by Glucotrol, glyburide by Diabeta and glimepiride by Amaryl. Primarily, sulfonylureas work through the augmentation of endogenous insulin emissions and as a result can only be used for patients who have viable B-cells.
The benefits of achieving optimal levels in blood glucose in patients with diabetes are currently well received, thanks to a multitude of clinical trials set out in table form. Best sulfonylurea for elderly patients is only one of many oral medications available for the treatment of diabetes. To optimize the control of blood sugar levels, it is important that medication regimens are based on factors that are patient specific, to minimize mortality and morbidity. The following factors are considered when deciding on a medication regimen:
- The glycemic control desired.
- The weight of the patient.
- The patient’s lipid profile.
- Contraindications – 2% to 4% of patients experience hypoglycemia per year; on average patients gain 4 – 6 kg in weight; gastrointestinal problems; dermatological reactions.
- Cost – sulfonylureas are the most cost effective compared to similar anti-diabetic medications.
It is important for patients who have been newly diagnosed with Type 2 diabetes to undergo a trial of exercise and dietary modifications initially. Many will require mono-therapy, with sulfonylurea as a first-line pharmacologic treatment. If control is inadequate with mono-therapy, other agents may be required. Insulin therapy could be added to best sulfonylurea for elderly patients for additional control of blood glucose.
Anti-diabetic medication can be taken in isolation or combined with other oral agents for effective Type 2 diabetes treatment. The best sulfonylurea for elderly patients is safe therapy, short term, as a result of SUR1 mutations and could potentially replace insulin injections successfully.
The effects on lipids, glucose, adverse reactions and elimination must be considered when selecting anti-diabetic agents, and treatments tailored to the needs and goals of the individual.