Choosing the correct type of Sulfonylurea
If you are struggling to control your Type-2 diabetes, then what can be more worthwhile than Sulfonylurea derivatives? These derivatives work in a simple way, by administering insulin discharge right from the beta cells situated in pancreas. Since there are, various derivatives you may get confused while deciding on which sulfonylurea to choose. However, these drugs come with restrictions like they are unsuitable for gestational diabetes. They are composed exclusively for Type-2, diabetes and fail to produce any curative effect on other types of diabetes. However, that was not the case in earlier days, this single Sulfonylurea was used extensively to treat all kinds of diabetes but it was in 1990s that a new twist was observed. Comparatively metformin proved more beneficial for obese diabetic patients than Sulfonylurea.
However, no matter what drug is used, Sulfonylurea is popular in controlling diabetes quite extensively. There are patients whose bodies demand more to challenge the disease. Hence, to control blood glucose density in them sulfonylurea’s requires companions- metformin or thiazolidinedione. Often doctors divert a little and resort to triple therapy curative measure involving sulfonylureas, thiazolidinedione, biguanide. Insulin however arrives eventually in the scenario if all these drugs fail to overpower glucose excess making it highly important as which sulfonylurea to choose.
Few prominent side effects of Sulfonylurea
Metformin and thiazolidinediones do not induce hypoglycemia but sulfonylurea’s does. When insulin production exceeds then Sulfonylurea’s stimulate hypoglycemia extensively. In such stage, you have to take maximum sugary food and you may need to take intravenous dextrose as well. However, the lowest feasible dose can restrict hypoglycemic coma. To avert any such circumstances you have to manage doses and settle on which sulfonylurea to choose to control glucose levels. Moreover, sulfonylurea’s, similar to insulin, can encourage body to gain some extra pounds. There are other insignificant side effects like headache and abdominal disorder, hypersensitivity issues.
Sulfonylurea’s is a big NO during pregnancy
Sulfonylurea’s derivatives are the least prescribed drug during pregnancy. Sulfonylurea’s are authentically teratogenic and during pregnancy and its intake can cause serious health hazards. It can cause birth defects and in the end generate liver problems or generate possibilities of hypoglycemia. No other drug except insulin can be used during pregnancy and hepatic and renal malfunctioning as well. If you are pregnant and running in your preliminary stage don’t think of which sulfonylurea to choose as this may hamper the natural development of the fetus.
Two generation of Sulfonylurea
The first generation sulfonylurea’s comprise, tolbutamide, chlorpropamide, acetohexamide tolazamide and, oral hypoglycemic agent. They are exploited extensively in therapy of Type-2 diabetes. They are recognized worldwide but exceptional reasons of clinically evident liver injury. Then the second generation sulfonylurea’s contain glyburide, glimepiride , glipizide and gliclazide which are basically oral hypoglycemic agents and are broadly exploited as curative measure in Type-2 diabetes. These agents are however occasional causes of clinically perceptible liver injury. Now it is up to you which sulfonylurea to choose and which not.
If you are suffering from diabetes then before turning your attention to insulin you must give one last look to sulfonylureas. Sulfonylurea’s derivatives are effective and despite having few side effects they are still counted as one of the best therapeutic measures to cure in Type-2, diabetes.